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PLGA-b-PGlu is pH responsive amphiphilic block copolymer, consisting of a PLGA random copolymer and a hydrophilic responsive block Polyglutamic acid. a= Lactide content, m = Glycolide content, m = Polyglutamic acid content.
PLGA is the key component of long acting drug products responsible for providing sustained release in a controlled manner.
PGlu is responsible pH sensitivity PLGA is a well-known biodegradable polyester which degrades in the human body by random chain hydrolysis into its non-toxic monomeric components lactic acid and glycolic acid.