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PEI, PEOZ and PEI based block copolymers

Description

The success of polyethyleneimine (PEI) as a nonviral-based gene delivery vector

Linear Polyethylenimine, Poly2-ethyloxazoline having repeating unit composed of the amine group/Oxazoline group and two carbon aliphatic spacer.

Performance Properties

  • PEI has a high charge density, enabling strong interactions with negatively charged DNA
  • PEI based block copolymers able to self assembled structure
  • PEOZ is amorphous and water soluble with good temperature stability
  • Biocompatibility, no accumulation in tissue, and rapid clearance from the bloodstream
  • Adhesion promoter in coatings.