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PEI, PEOZ and PEI based block copolymers

The success of polyethyleneimine (PEI) as a nonviral-based gene delivery vector

Linear Polyethylenimine, Poly2-ethyloxazoline having repeating unit composed of the amine group/Oxazoline group and two carbon aliphatic spacer.

PEI has a high charge density, enabling strong interactions with negatively charged DNA
PEI based block copolymers able to self assembled structure
PEOZ is amorphous and water soluble with good temperature stability
Biocompatibility, no accumulation in tissue, and rapid clearance from the bloodstream
Adhesion promoter in coatings.